diff --git a/federationsender/storage/sqlite3/storage.go b/federationsender/storage/sqlite3/storage.go
index 7ba51fb5..7fe6b65b 100644
--- a/federationsender/storage/sqlite3/storage.go
+++ b/federationsender/storage/sqlite3/storage.go
@@ -35,7 +35,9 @@ type Database struct {
 	queuePDUsStatements
 	queueJSONStatements
 	sqlutil.PartitionOffsetStatements
-	db *sql.DB
+	db              *sql.DB
+	queuePDUsWriter *sqlutil.TransactionWriter
+	queueJSONWriter *sqlutil.TransactionWriter
 }
 
 // NewDatabase opens a new database
@@ -74,6 +76,9 @@ func (d *Database) prepare() error {
 		return err
 	}
 
+	d.queuePDUsWriter = sqlutil.NewTransactionWriter()
+	d.queueJSONWriter = sqlutil.NewTransactionWriter()
+
 	return d.PartitionOffsetStatements.Prepare(d.db, "federationsender")
 }
 
@@ -145,12 +150,16 @@ func (d *Database) GetJoinedHosts(
 // metadata entries.
 func (d *Database) StoreJSON(
 	ctx context.Context, js string,
-) (int64, error) {
-	nid, err := d.insertQueueJSON(ctx, nil, js)
-	if err != nil {
-		return 0, fmt.Errorf("d.insertQueueJSON: %w", err)
-	}
-	return nid, nil
+) (nid int64, err error) {
+	err = d.queueJSONWriter.Do(d.db, func(txn *sql.Tx) error {
+		n, e := d.insertQueueJSON(ctx, nil, js)
+		if e != nil {
+			return fmt.Errorf("d.insertQueueJSON: %w", e)
+		}
+		nid = n
+		return nil
+	})
+	return
 }
 
 // AssociatePDUWithDestination creates an association that the
@@ -162,7 +171,7 @@ func (d *Database) AssociatePDUWithDestination(
 	serverName gomatrixserverlib.ServerName,
 	nids []int64,
 ) error {
-	return sqlutil.WithTransaction(d.db, func(txn *sql.Tx) error {
+	return d.queuePDUsWriter.Do(d.db, func(txn *sql.Tx) error {
 		for _, nid := range nids {
 			if err := d.insertQueuePDU(
 				ctx,           // context
@@ -230,18 +239,18 @@ func (d *Database) CleanTransactionPDUs(
 	serverName gomatrixserverlib.ServerName,
 	transactionID gomatrixserverlib.TransactionID,
 ) error {
-	return sqlutil.WithTransaction(d.db, func(txn *sql.Tx) error {
-		nids, err := d.selectQueuePDUs(ctx, txn, serverName, transactionID, 50)
+	var err error
+	var nids []int64
+	var deleteNIDs []int64
+	if err = d.queuePDUsWriter.Do(d.db, func(txn *sql.Tx) error {
+		nids, err = d.selectQueuePDUs(ctx, txn, serverName, transactionID, 50)
 		if err != nil {
 			return fmt.Errorf("d.selectQueuePDUs: %w", err)
 		}
-
 		if err = d.deleteQueueTransaction(ctx, txn, serverName, transactionID); err != nil {
 			return fmt.Errorf("d.deleteQueueTransaction: %w", err)
 		}
-
 		var count int64
-		var deleteNIDs []int64
 		for _, nid := range nids {
 			count, err = d.selectQueueReferenceJSONCount(ctx, txn, nid)
 			if err != nil {
@@ -251,15 +260,19 @@ func (d *Database) CleanTransactionPDUs(
 				deleteNIDs = append(deleteNIDs, nid)
 			}
 		}
-
+		return nil
+	}); err != nil {
+		return err
+	}
+	err = d.queueJSONWriter.Do(d.db, func(txn *sql.Tx) error {
 		if len(deleteNIDs) > 0 {
 			if err = d.deleteQueueJSON(ctx, txn, deleteNIDs); err != nil {
 				return fmt.Errorf("d.deleteQueueJSON: %w", err)
 			}
 		}
-
 		return nil
 	})
+	return err
 }
 
 // GetPendingPDUCount returns the number of PDUs waiting to be