diff --git a/federationapi/queue/queue.go b/federationapi/queue/queue.go
index 5b548127..c45bbd1d 100644
--- a/federationapi/queue/queue.go
+++ b/federationapi/queue/queue.go
@@ -210,6 +210,7 @@ func (oqs *OutgoingQueues) SendEvent(
 		destmap[d] = struct{}{}
 	}
 	delete(destmap, oqs.origin)
+	delete(destmap, oqs.signing.ServerName)
 
 	// Check if any of the destinations are prohibited by server ACLs.
 	for destination := range destmap {
@@ -275,6 +276,7 @@ func (oqs *OutgoingQueues) SendEDU(
 		destmap[d] = struct{}{}
 	}
 	delete(destmap, oqs.origin)
+	delete(destmap, oqs.signing.ServerName)
 
 	// There is absolutely no guarantee that the EDU will have a room_id
 	// field, as it is not required by the spec. However, if it *does*
diff --git a/federationapi/routing/send.go b/federationapi/routing/send.go
index f2b902b6..2c01afb1 100644
--- a/federationapi/routing/send.go
+++ b/federationapi/routing/send.go
@@ -124,6 +124,7 @@ func Send(
 	t := txnReq{
 		rsAPI:                  rsAPI,
 		keys:                   keys,
+		ourServerName:          cfg.Matrix.ServerName,
 		federation:             federation,
 		servers:                servers,
 		keyAPI:                 keyAPI,
@@ -183,6 +184,7 @@ type txnReq struct {
 	gomatrixserverlib.Transaction
 	rsAPI                  api.RoomserverInternalAPI
 	keyAPI                 keyapi.KeyInternalAPI
+	ourServerName          gomatrixserverlib.ServerName
 	keys                   gomatrixserverlib.JSONVerifier
 	federation             txnFederationClient
 	roomsMu                *internal.MutexByRoom
@@ -303,6 +305,7 @@ func (t *txnReq) processTransaction(ctx context.Context) (*gomatrixserverlib.Res
 	return &gomatrixserverlib.RespSend{PDUs: results}, nil
 }
 
+// nolint:gocyclo
 func (t *txnReq) processEDUs(ctx context.Context) {
 	for _, e := range t.EDUs {
 		eduCountTotal.Inc()
@@ -318,13 +321,11 @@ func (t *txnReq) processEDUs(ctx context.Context) {
 				util.GetLogger(ctx).WithError(err).Debug("Failed to unmarshal typing event")
 				continue
 			}
-			_, domain, err := gomatrixserverlib.SplitID('@', typingPayload.UserID)
-			if err != nil {
-				util.GetLogger(ctx).WithError(err).Debug("Failed to split domain from typing event sender")
+			if _, serverName, err := gomatrixserverlib.SplitID('@', typingPayload.UserID); err != nil {
 				continue
-			}
-			if domain != t.Origin {
-				util.GetLogger(ctx).Debugf("Dropping typing event where sender domain (%q) doesn't match origin (%q)", domain, t.Origin)
+			} else if serverName == t.ourServerName {
+				continue
+			} else if serverName != t.Origin {
 				continue
 			}
 			if err := t.producer.SendTyping(ctx, typingPayload.UserID, typingPayload.RoomID, typingPayload.Typing, 30*1000); err != nil {
@@ -337,6 +338,13 @@ func (t *txnReq) processEDUs(ctx context.Context) {
 				util.GetLogger(ctx).WithError(err).Debug("Failed to unmarshal send-to-device events")
 				continue
 			}
+			if _, serverName, err := gomatrixserverlib.SplitID('@', directPayload.Sender); err != nil {
+				continue
+			} else if serverName == t.ourServerName {
+				continue
+			} else if serverName != t.Origin {
+				continue
+			}
 			for userID, byUser := range directPayload.Messages {
 				for deviceID, message := range byUser {
 					// TODO: check that the user and the device actually exist here
@@ -405,6 +413,13 @@ func (t *txnReq) processPresence(ctx context.Context, e gomatrixserverlib.EDU) e
 		return err
 	}
 	for _, content := range payload.Push {
+		if _, serverName, err := gomatrixserverlib.SplitID('@', content.UserID); err != nil {
+			continue
+		} else if serverName == t.ourServerName {
+			continue
+		} else if serverName != t.Origin {
+			continue
+		}
 		presence, ok := syncTypes.PresenceFromString(content.Presence)
 		if !ok {
 			continue
@@ -424,7 +439,13 @@ func (t *txnReq) processSigningKeyUpdate(ctx context.Context, e gomatrixserverli
 		}).Debug("Failed to unmarshal signing key update")
 		return err
 	}
-
+	if _, serverName, err := gomatrixserverlib.SplitID('@', updatePayload.UserID); err != nil {
+		return nil
+	} else if serverName == t.ourServerName {
+		return nil
+	} else if serverName != t.Origin {
+		return nil
+	}
 	keys := gomatrixserverlib.CrossSigningKeys{}
 	if updatePayload.MasterKey != nil {
 		keys.MasterKey = *updatePayload.MasterKey
@@ -450,6 +471,13 @@ func (t *txnReq) processReceiptEvent(ctx context.Context,
 	timestamp gomatrixserverlib.Timestamp,
 	eventIDs []string,
 ) error {
+	if _, serverName, err := gomatrixserverlib.SplitID('@', userID); err != nil {
+		return nil
+	} else if serverName == t.ourServerName {
+		return nil
+	} else if serverName != t.Origin {
+		return nil
+	}
 	// store every event
 	for _, eventID := range eventIDs {
 		if err := t.producer.SendReceipt(ctx, userID, roomID, eventID, receiptType, timestamp); err != nil {
@@ -466,6 +494,13 @@ func (t *txnReq) processDeviceListUpdate(ctx context.Context, e gomatrixserverli
 		util.GetLogger(ctx).WithError(err).Error("Failed to unmarshal device list update event")
 		return
 	}
+	if _, serverName, err := gomatrixserverlib.SplitID('@', payload.UserID); err != nil {
+		return
+	} else if serverName == t.ourServerName {
+		return
+	} else if serverName != t.Origin {
+		return
+	}
 	var inputRes keyapi.InputDeviceListUpdateResponse
 	t.keyAPI.InputDeviceListUpdate(context.Background(), &keyapi.InputDeviceListUpdateRequest{
 		Event: payload,
diff --git a/keyserver/internal/internal.go b/keyserver/internal/internal.go
index e70de767..e571c7e5 100644
--- a/keyserver/internal/internal.go
+++ b/keyserver/internal/internal.go
@@ -71,8 +71,12 @@ func (a *KeyInternalAPI) QueryKeyChanges(ctx context.Context, req *api.QueryKeyC
 
 func (a *KeyInternalAPI) PerformUploadKeys(ctx context.Context, req *api.PerformUploadKeysRequest, res *api.PerformUploadKeysResponse) {
 	res.KeyErrors = make(map[string]map[string]*api.KeyError)
-	a.uploadLocalDeviceKeys(ctx, req, res)
-	a.uploadOneTimeKeys(ctx, req, res)
+	if len(req.DeviceKeys) > 0 {
+		a.uploadLocalDeviceKeys(ctx, req, res)
+	}
+	if len(req.OneTimeKeys) > 0 {
+		a.uploadOneTimeKeys(ctx, req, res)
+	}
 }
 
 func (a *KeyInternalAPI) PerformClaimKeys(ctx context.Context, req *api.PerformClaimKeysRequest, res *api.PerformClaimKeysResponse) {
@@ -663,6 +667,7 @@ func (a *KeyInternalAPI) uploadLocalDeviceKeys(ctx context.Context, req *api.Per
 		// add the display name field from keysToStore into existingKeys
 		keysToStore = appendDisplayNames(existingKeys, keysToStore)
 	}
+
 	// store the device keys and emit changes
 	err = a.DB.StoreLocalDeviceKeys(ctx, keysToStore)
 	if err != nil {